![]() In a recent genome wide association meta-analysis, researchers uncover new risk factors for the poorly-understood SCAD. The most common form of heart disease, coronary artery disease (CAD), is caused by plaque buildup, while spontaneous coronary artery dissection (SCAD) is caused by a tear in the artery wall. Heart disease that presents with the same end symptoms, like a heart attack, can be caused by different underlying mechanisms. Linking Transcription Factors Turns Cancer Drivers into Cancer Killers - Bridge Informatics ![]() In this particular lymphoma subtype, BCL6 exhibits binding to the promoters of cell death genes and, through epigenetic modifications, suppresses their expression.īy harnessing the intrinsic properties of the cancer cell, these researchers were able to “flip the switch” from cancerous growth to death of cancer cells. Sai Gourisankar study focused on a diffuse B cell #lymphoma model characterized by the significant dysregulation of the transcription factor BCL6. explored the idea that #CIPs could be used to link distinct cellular processes – artificially inducing proximity between two #molecules that would otherwise not meet to activate a new process. In a recent Nature Portfolio paper, Sai Gourisankar et al. ![]() Could it be possible to redirect these cancer-promoting mechanisms towards triggering pathways that lead to cell death instead? It is widely recognized that cancer cells have the capability to inhibit the activation of pro-apoptotic (cell death-inducing) genes while concurrently enhancing the activation of genes associated with growth. This approach, which uses translational/epigenetic chemical inducers of proximity #TCIPs can potentially be applied to #therapeutics applications beyond cancer as well. What if you could turn a #cancer cell against itself? In a remarkable recent paper, a team of researchers used the intrinsic properties of a cancer driver #protein that suppresses cell death to make it activate cell death instead. QIAGEN Digital Insights launches ultra-fast NGS analysis able to process a whole genome in 25 minutes for a $1 in cloud computing costs #data #technology #software #dataanalytics "Thanks to LightSpeed’s ground-breaking technology, #WGS analysis is extremely fast, beats most other #FASTQ to #VCF workflows on accuracy, uses less power and requires no investments in new hardware or software licenses beyond #CLC.”Ī huge step forward in the accelerastion of #bioinformatics and #genomics to identify and treat disease. Jonathan Sheldon, Senior Vice President of QIAGEN Digital Insights. “QIAGEN CLC Genomics Workbench Premium is much faster, more accurate, greener and cheaper than previous data-analysis and visualization solutions,” said Dr. ![]() QIAGEN Digital Insights the #bioinformatics business of QIAGEN, today announced their enhanced QIAGEN CLC Genomics Workbench Premium that removes the #data-analysis bottleneck of next-generation sequencing #ngs by adding game-changing analysis speed to analyze and interpret whole genome sequencing #WGS, whole exome sequencing #WES and large panel sequencing data. □ □ QIAGEN Moving at Electric Pace □ □
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